Summary
Mass Effect: Andromedamay not have been as well-regarded as the original trilogy, but its companions could still potentially play a role inMass Effect 4. Depending on where in the timelineMass Effect 4ends up taking place, the events and characters ofMass Effect: Andromedacould end up being more relevant than expected. Of course, there may be a few hurdles to overcome, most notably the fact thatAndromedatakes place in an entirely different galaxy from the first three games. However, depending on the details ofMass Effect 4, some of these problems could be solved.
After three beloved games,Mass Effect: Andromedastruggled at launch, disappointing many fans. Granted, while the game did have some legitimate issues, one of its biggest concerns may have been following up on the sky-high expectations left by the original trilogy. To its credit,Andromedadid create a lot of new worlds for players to explore, and the gameplay could be pretty exciting. However, writing that lacked the strength of the originals combined with technical issues held the game back. Regardless, its positive attributes have managed to be remembered, even though the series seems to be leaving the Andromeda galaxy for the next installment, and those positive attributes include the game’s companions.

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Andromeda’s Companions Could Find a Place in Mass Effect 4
So far, while some information implies thatMass Effect 4is abandoningAndromeda’s open world, not everything aboutAndromedaneeds to be left in the past. The most prominent example of this would be the game’s crewmates themselves. While they only got one game to show off their personalities, as opposed to some of the original trilogy crew getting up to three, several of them still have plenty of room to tell interesting stories if they come back. However, considering thatAndromedatakes place 600 years after the original trilogy,Mass Effect 4would likely require a similar time skip for any such cameos.
While the return ofAndromeda’s crewmates may not be compatible with apotential Shepard return inMass Effect 4, there are still a few arguments in its favor. Many members of the crew are space faring adventurers who could conceivably make an appearance despite hailing from another galaxy. In particular, Vetra and Peebee both had a long history of exploring the universe before they joined up with Ryder. Depending on whether they stuck with Ryder after the events of the game, they could very well continue their adventures after the fact, and if they ever reached the Milky Way, they could appear inMass Effect 4.
The most interesting character worth seeing again may be Drack due to how he could affectMass Effect 4’s approach to the Krogan. The krogan have been a major part ofMass Effectsince the beginning, and Drack is a legend among the krogan, being a long-lived warrior who has survived countless wars. Since the krogan are almost certain to return, seeing Drack again may be as good as meeting Wrex once more. He could provide another window into the history of the krogan. Of course, Drack also has the benefit of his amusingly grumpy personality that can lead to many amusing interactions.
Provided that there is a way to cross the distance between the Andromeda galaxy and the Milky Way, there is a chance forMass Effect 4to take inspiration fromAndromedaby bringing back some of its companions for a second role. Whether they act as NPCs and quest givers, or even become crewmates once more, as long as there’s a way to fit them intoMass Effect 4, they don’t have to be one-off characters in the series.Mass Effect: Andromedamay have thrown the timeline forward, but that doesn’t meanMass Effect 4will leave its cast out completely.